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KMID : 1035520190070010048
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Brain Tumor Research and Treatment : BTRT
2019 Volume.7 No. 1 p.48 ~ p.52
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Choroid Plexus Carcinoma in Adults: Two Case Reports
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Kim Tae-Hoon
Park Mee-Rim
Hong Eun-Kyeong
Gwak Ho-Shin
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Abstract
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Choroid plexus tumors are uncommon brain tumors that primarily occur in children. Most of these tumors originate from the intraventricular area, and the most common clinicalpresentation is increased intracranial pressure. Dissemination through the cerebrospinal fluid space is the inevitable natural course of the disease. Here, we present 2 rare cases of adult choroid plexus carcinoma (CPC), each with distinct clinical presentation and progression. The first case was a 40-year-old male who presented with multiple intraventricular masses. After surgical biopsy, radiation and intrathecal chemotherapy failed to elicit any response. The patient progressed with spinal cord dissemination and expired 1 year later. The second case presented with visual disturbance, and brain MRI revealed a large ovoid juxtaventricular mass with peritumoral edema. This 49-year-old female patient underwent craniotomy for what was thought to be a high-grade glioma; however, the mass was connected to the choroid plexus at the operative field. Her pathology specimen was diagnosed as CPC, and adjuvant systemic chemotherapy was administered. She has now been free of recurrence for 10 months. The description of the presentation and progression of these rare adult-onset CPC provides insight for the diagnosis and treatment of other rare instances of choroid plexus tumors.
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KEYWORD
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Adult, Cerebrospinal fluid, Choroid plexus carcinoma, Fourth ventricle
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